Postmortem Fluid and Tissue Concentrations of THC, 11-OH-THC and THC-COOH†
نویسندگان
چکیده
منابع مشابه
New extraction method of THC and its metabolites, 11-OH-THC and THC-COOH, in plasma
Objectives: A liquid/liquid extraction technique on solid support of Δ9-tetradydrocannabinol (THC), 11-hydroxy-Δ9-tetradydrocannabinol (11-OH-THC) and 11-nor-Δ9-tetradydrocannabinol-9-carboxylic acid (THCCOOH) in plasma was developed in order to be assayed by high-performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS). Methods: The samples were extracted by liquid/liquid ex...
متن کاملSimultaneous and sensitive analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in plasma after oral application of small doses of THC and cannabis extract.
Besides the psychoactive Delta(9)-tetrahydrocannabinol (THC), hashish and marijuana as well as cannabis-based medicine extracts contain varying amounts of cannabidiol (CBD) and of the degradation product cannabinol (CBN). The additional determination of these compounds is interesting from forensic and medical points of view because it can be used for further proof of cannabis exposure and becau...
متن کاملDevelopment and validation of an automated liquid-liquid extraction GC/MS method for the determination of THC, 11-OH-THC, and free THC-carboxylic acid (THC-COOH) from blood serum
The analysis of Δ(9)-tetrahydrocannabinol (THC) and its metabolites 11-hydroxy-Δ(9)-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THC-COOH) from blood serum is a routine task in forensic toxicology laboratories. For examination of consumption habits, the concentration of the phase I metabolite THC-COOH is used. Recommendations for interpretation of analysis v...
متن کاملHigh-throughput toxicological analysis of Δ9-THC and 11-nor-9-carboxy-Δ9-THC by LC/MS/MS
A new high-throughput liquid chromatography / tandem mass spectrometry (LC-MS/MS) method for the quantification of Δ-tetrahydrocannabinol (THC) in suspect plant material and of its principal metabolite, 11-nor-9carboxy-Δ-tetrahydrocannabinol (THC-COOH), in human urine was developed and validated. The separation was performed on a Zorbax SB-C18 column under isocratic conditions using a mixture o...
متن کاملTHC Prevents MDMA Neurotoxicity in Mice
The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidan...
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ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2017
ISSN: 0146-4760,1945-2403
DOI: 10.1093/jat/bkx033